Formulating a strong clinical question is the first step in the research process. PICO is a way of building clinical research questions that allow you to focus your research, and to create a query that better matches most medical databases.
- Patient – Describe your patient or population. What are the most important characteristics? Include information on age, race, gender, medical conditions, etc.
- Intervention – What is the main intervention or therapy you are considering? The can be as general as treat or observe, or as specific as a specific test or therapy.
- Comparison Intervention – An alternative intervention or therapy you wish to compare to the first.
- Outcome – What are you trying to do for the patient? What is the clinical outcome? What are the relevant outcomes?
Example: In a (describe patient) can (intervention A) affect (outcome) compared with (intervention B)?
- In a 50 year old man with diabetes is weight loss and exercise or medication better at maintaining healthy blood sugar levels?
- Patient - 50 yr old man with diabetes
- Intervention - weight loss and exercise
- Comparison - medication
- Outcome - maintaining blood sugar levels